Microcalorimetric Titration of a-Cyciodextrin with some Straight-chain Alkan-1-01s at 288.1

The binding of a series of alkan-1-ols, n, = 3-7, to a-cyclodextrin has been investigated by microcalorimetric titration at 288.1 5, 298.1 5 and 308.1 5 K. For nc < 6, the results agree well with a 1 : 1 binding model but for nc = 7, contributions from the formation of 1 : 2 (one alkanol, two a-CD) complexes have to be assumed. Apparent values for changes in standard molar Gibbs energies, enthalpies, entropies and heat capacities have been derived. The values obtained are consistent with the commonly held view that hydrophobic interactions are important in t h e formation of alkanol-a-CD complexes. However, t h e results clearly indicate that other effects are also of some importance.